Statistical Bioinformatics Seminar: Dr Luca Pinello

Speaker: Dr Luca Pinello, Harvard Medical School 

Abstract: In this talk, Dr Luca Pinello will present an overview of his lab’s recent
work at the intersection of CRISPR genome editing, single-cell omics assays, and
generative AI to elucidate gene regulation.  His lab’s research focuses on developing
computational methods to investigate genotype-phenotype relationships at high
resolution, infer dynamic gene regulatory networks, and integrate multi-omics data.  By
leveraging state-of-the-art technologies and advanced computational approaches, his lab
aims to uncover the complexities of cellular heterogeneity, identify key regulatory
elements and transcription factors, and understand the interplay between chromatin
structure and function in normal development and disease.  

About the speaker: Luca Pinello is a computational biologist and leader in developing
computational methods for functional genomics, genome editing and single cell
technologies.  He holds a Ph.D.  in Mathematics and Computer Science from University of
Palermo, Italy.  He is currently an Associate Pathologist at Massachusetts General
Hospital (MGH) and an Associate Professor of Pathology at Harvard Medical School.  He is
also part of the MGH Center for Cancer Research and an Associate Member of the BROAD
Institute of MIT and Harvard.  He has developed several foundational computational tools
in the field of genome editing for the design (CRISPRme, CRISPRitz, PrimeDesign),
quantification (CRISPResso 1 and 2), and analyses of coding and non-coding tiling
screens (CRISPRO, CRISPR-SURF).  He was awarded one of the first NIH R35 Genomic
Innovator Awards, a prestigious grant supporting highly innovative researchers working
on important problems in genomics.  

Join on Zoom: https://uni-sydney.zoom.us/j/85114748391